Thrombin generation can be driven by prothrombin activation on the surface of striated muscle myosin-anionic PL complexes that bind FXa and FVa. The intrinsic and extrinsic coagulation pathways converge at the generation of FXa, which is the key enzyme that activates prothrombin. As depicted, both FXa and its cofactor FVa bind to myosin-PL, which potently promotes prothrombin activation to generate thrombin. Prothrombin might bind to FVa and myosin and also to PLs via its Gla domain.