ELOVL6 regulates resistance to BTZ in MM cells. MM.1S and RPMI8226 cells were transduced with empty vector (vector), ELOVL6 cDNA-expressing vector (E6 cDNA), control shRNA (CL), or ELOVL6 shRNAs (E1 or E2). The resulting cell populations were subjected to lipidomic analysis in independent triplicates 48 hours postinfection. Shown are means of the individual lipid ratios between MM cell populations that were calculated and plotted as heatmaps for the following lipid classes using Microsoft R Open (version 3.5.1) software: –ceramides (CER), glycosylceramides (GL-CER), diacylglycerides (DG), –phosphatidylcholine (PC), –phosphatidylethanolamine (PE), –phosphatidylglycerol (PG), –phosphatidylserine (PS), –phosphatidylinositol (PI), and –triglycerides (TG). Only lipid classes with >20 species per lipid class are shown. The heatmaps consist of individual lipid species ratios. A scale for the number of individual lipid species ratios is shown on the right.