Clonal architecture can follow 2 types of organization: linear and branched evolution. (A) Linear evolution refers to a Russian doll-like organization where each new clone occurs inside the previous one. Thus, each new clone inherits all of the previous mutations. (B) Branched evolution refers to parallel evolution of different clones. These 2 clonal architectures can be represented in various ways, including phylogenetic trees that reconstruct the occurrence of mutations through time (top), fishplots that, in addition, represent the growth of each new clone through time (middle), or slices that capture the clonal architecture similarly to the fishplot but at a particular time point (bottom).