Atypical double-hit tumors do not share a similar GEP as HGBL-DH/TH-BCL2 tumors. (A) DHITsig score and COO linear predictor score are shown for HGBL-DH/TH-BCL2, atypical double-hit, and not otherwise specified tumors. Dotted lines indicate cutoffs between molecular subtype classifications as shown in the figure key. Forest plots show the odds ratios with 95% confidence intervals of belonging to the DHITsig+ subtype for each indicated subgroup of atypical double-hit tumors compared with tumors with MYC rearrangement alone (MYC^Tr/BCL2^Normal) (B) or BCL2 rearrangement alone (MYC^Normal/BCL2^Tr) (C).