Pooled treated ABR and by HAVEN study across 24-week treatment intervals. 95% CI for the mean were calculated via the exact Poisson method. A treated bleed was defined as a bleed followed by treatment of a bleed; bleeds due to surgery/procedures were excluded. Only data for time intervals with ≥10 participants are reported; for inclusion within a time window, participants needed to have completed the entire 24-week interval (without uptitration). *Based on the calculated ABR for bleeds treated with coagulation factors. NE, not estimated.