Figure 6.
A combination treatment of Ara-C with Baf A1 leads to enhanced antileukemic activity. NSG mice were injected via tail vein with luciferase-transfected MOLM-13 cells. Mice were divided into groups of 5 animals and treated with vehicle (DMSO), Ara-C (60 mg/kg per day: 5 days on, 4 days off, 5 days on), Baf A1 (1 mg/kg 3 times a week every other day for 21 days), or in combination. (A) Whole-animal bioluminescence imaging on day 14 after treatment. (B) Quantification of bioluminescence shown as average total photon flux per second on days 14 and 21 after treatment initiation. Error bars represent ± standard deviation. *P < .05, **P < .01.