Effects of WNT inhibition on GVL and survival in the A20 leukemia model. (A) In mice injected with 20 000 A20 cells, comparable survival times were noted in G007-LK–, pyrvinium-, salinomycin-, or vehicle-treated mice with syngeneic or allogeneic transplantation. Survival over time is shown as Kaplan-Meier curves. P < .005, allogeneic vs syngeneic. For WNT inhibitor treatment groups, no significant differences compared with vehicle-treated mice (n = 8 mice per group). (B) Percentage of yfp⁺ tumor cells in the peripheral blood of G007-LK–, pyrvinium-, salinomycin-, or sham-treated mice with syngeneic or allogeneic transplantation injected with A20 yfp/luc cells, as determined by flow cytometry on days 11, 16, and 25 post–A20 injection (n = 8 mice per group). *P < .5; **P < .05; ***P < .01. ns, not significant.