Five-year cumulative incidence of relapse.KMT2D mutational status (A), KMT2D and PTEN mutational status (B), KMT2D and PTEN mutational status on an N/F^wt background (C) and KMT2D and PTEN mutational status on an N/F^mut background (D). A VAF cutoff of >10% and only nonsynonymous mutations were included for analysis. In case of N/F^mut, only mutations from the hotspots (exons 26, 27, and 34 for NOTCH1 and exons 9, 10, and 12 for FBXW7) were included.