FLT-3 JMD deletions can be targeted by FLT-3 TKIs. Cells expressing the FLT-3 JMD deletions or FLT-3/ITD mutations were exposed to increasing concentrations of the indicated FLT-3 TKIs for 48 hours. The colorimetric MTT assay was used to measure growth. Proliferation, normalized to untreated cells, was plotted as a function of TKI concentration.