MK-6482 decreased the elevated expression of Cxcl-12 in Vhl^R200W mice. (A) Cxcl-12 protein levels were significantly increased in the serum of Vhl^R200W mice. When treated with MK-6482, serum Cxcl-12 protein reverted to WT levels. Cxcl-12 mRNA expression levels in lung (B) and heart (C) were elevated in the Vhl^R200W mice. Drug treatment significantly reduced the Cxcl12 mRNA levels. **P < .01; ***P < .001, by ordinary 1-way ANOVA (multiple comparisons). D-mutant, double-mutant Vhl^R200W;Irp1-KO mouse.