Pracinostat induces acetylation of core histones and nonhistone proteins. DLBCLs were treated with DMSO (–) or pracinostat (+) for 6 hours (A) or 72 hours (B) before protein extraction and western blotting analysis. For each panel, OxPhos-DLBCLs are to the left of the dashed line and BCR-DLBCLs are to the right. Pracinostat induced acetylation of core histones at both time points. Quantification of acetylated protein bands is shown on the right side of the immunoblots and was performed using ImageJ.