TE and MB incidence rates (% ppy) over 30 months; 12 months before, and 18 months after, monitoring test replacement. Incidence of composite TE (A) and MB (B) during each of the PT, transition, and Fiix periods (box plots with 90% range). TE incidence (C,E) and MB incidence (D,F) per 100 patient years at consecutive monthly intervals over the entire 30-month course. Two-segmented (C-D) and 3-segmented (E-F) regression lines (solid lines), 95% CIs (dotted lines), and R² values are shown for the overall plots.