Distribution of SNVs, InDels, and CNAs across patients and samples. Genes that were recurrent in the tissue-RS (A) and total number of mutated samples per recurrent gene and by DNA source (B). Recurrent genes were those harboring (1) an SNV/InDel in ≥ 2 tissue-RS samples or (2) an SNV/InDel or CNA ≥2 tissue-RS samples and constituted any of 46 cancer pathways or CLL drivers or DDR genes. Red gene labels in panel A indicate CLL drivers and orange labels indicate DDR genes. Gray dots indicate cases with MYC overexpression in the tissue-RS.