Figure 4.
![Transitions in the values of CCFs of somatic mutations during transformation from CLL to RS in each CHOP-O patient. We observe clonal expansions (ie, cancer cell fractions [CCF] values increase from PB-CLL to tissue-RS), clonal contractions (ie, CCF values decrease from PB-CLL to tissue-RS) or clonal stability (ie, CCF values remain roughly the same between PB-CLL and tissue-RS). Each gray line indicates the transition of a single SNV/InDel from PB-CLL to tissue-RS. If a variant is absent in 1 phase, no transition line is shown.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/137/20/10.1182_blood.2020005650/1/bloodbld2020005650f4.png?Expires=1736042700&Signature=hS3vKk3Y0yzLUZSPVcwgZPBIFGxsJ2SZ3LWSXz2b8oVvFhWQLtraCSaa2IiglC5IYzxiYr-g4xtEV9nAfUMcRPmHMD4gGL36fq4wGlE1zSsGBuDDjvAhxW0EWDKWBDDTlmzLUq5L2xHuwKzqbUgDKdUNG~JmDucOXm5IY8SLMl5iCyEFwffnBomkMjfm~n5-beoB08Sm6pwYy7a3IQHCPXB7JEtpGzgEQQhnMqVRe4mdpKd8EJ4BYCKhQ2GvenDoNpQRsyCepwUtpU7GYYfOilcrwOegjZTI8RNUl4tXqlTVdkiJIHMwt9v4~5iMeIdnbxJjzJ90n0HVDIjP~S6fbg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Transitions in the values of CCFs of somatic mutations during transformation from CLL to RS in each CHOP-O patient. We observe clonal expansions (ie, cancer cell fractions [CCF] values increase from PB-CLL to tissue-RS), clonal contractions (ie, CCF values decrease from PB-CLL to tissue-RS) or clonal stability (ie, CCF values remain roughly the same between PB-CLL and tissue-RS). Each gray line indicates the transition of a single SNV/InDel from PB-CLL to tissue-RS. If a variant is absent in 1 phase, no transition line is shown.