Figure 1.
OCT1, OCT2, and OBF1 show genome-wide colocalization. (A-C) Venn diagrams showing the overlaps among OCT1, OCT2, and OBF1 peaks in LPS-stimulated splenic B cells. (D-F) Correlation of enrichment between OCT1 and OCT2 (D), OBF1 and OCT1 (E), and OBF1 and OCT2 (F) ChIP-seq samples under LPS stimulation. (G) Heatmap showing OCT1, OCT2, and OBF1 ChIP enrichment under LPS stimulation in 5-kb windows centered on OCT1 peak summits. (H) Mean of alignments of OCT1, OCT2, and OBF1 ChIP-seq signals centered on OCT1 peak summits within 5-kb genomic window under LPS stimulation. (I) OBF1/OCT1/OCT2 ChIP-seq read densities in LPS-stimulated mouse splenic B cells at 2 known OBF1 target gene loci. (J) Violin plots showing distributions of expression levels of genes grouped by their association with OBF1 (left), OCT1 (middle), or OCT2 (right) in splenic B cells stimulated with LPS. Mean ± standard deviation; *P < .05; **P < .01; ***P < .001; ****P < .0001 (Mann-Whitney U test).