Minimal structural differences exist between complexed FVIII and VWF-D′ compared with free FVIII and VWF-D′. (A) Superposition of complexed FVIII from this study (blue) and free FVIII from PDB: 6MF2 (black). (B) Superposition of complexed VWF-D′ from this study (red) and free VWF-D′ from PDB: 6N29 (black). The FVIII and VWF-D3 portions of the structure are in gray.