Elimination of myeloma cells by CT103A. (A) Comparison of an extramedullary lesion in the abdomen of patient 01-005 before and 98 days after CT103A infusion. The lesion was denoted by arrows in the left 2 images from the positron emission tomography/computed tomography scan before infusion. At day 98, after infusion, no lesion was observed in the 2 images on the right, which was nearly the same section as that on the positron emission tomography/computed tomography scan. (B) Change in the serum light chain levels in patient 01-001. After the murine BCMA CAR infusion, the serum light chain level decreased for a short time and soon recovered, and the PFS was 44 days. In comparison, after CT103A infusion, the light chain level quickly decreased and remained stable at a normal level with a normal κ/λ ratio, indicating continuous sCR. The PFS was 587 days at the cutoff date.