Disorder in the B domain limits resolution of the architecture of this portion of fV. (A) Several regions of the domain are detected as streaks that cover most of the A2 and A3 domains, as shown by the unmasked map at 4.1 Å resolution. The orientation of fV corresponds to that in Figure 2B, after rotation of 90° around the y-axis. The only ordered regions of the B domain (836 residues) are limited to 14 residues connecting to the A2 and A3 domains. (B) The N-terminal ⁷¹⁰SFRN⁷¹³ segment (light blue) connects to the A2 domain (pale green) (B) and the C-terminal ¹⁵³⁶PDNIAAWYLR¹⁵⁴⁵ segment (light blue) connects to the A3 domain (pale yellow) (C).