(A) Paired samples: SCD-Baseline and SCD-Crisis pairs (n = 18). Circles represent the mean of each sample. *P < .05, **P < .01, nonparametric Wilcoxon matched-pairs signed-rank test. (B) Quantitation of cf-mtDNA/cf-nDNA ratio using the following mitochondrial and nuclear targets: MT-ND1/GAPDH, MTND1/TERT, MT-ND6/GAPDH, and MT-ND6/TERT. Error bars represent the sample mean ± standard deviation. *P < .05, ***P < .0005, ****P < .0001, nonparametric Kruskal-Wallis test with Dunn’s multiple-comparison test. cf-nDNA, cell-free nuclear DNA. See the complete Figure 1 in the article by Tumburu et al that begins on page 3116.

(A) Paired samples: SCD-Baseline and SCD-Crisis pairs (n = 18). Circles represent the mean of each sample. *P < .05, **P < .01, nonparametric Wilcoxon matched-pairs signed-rank test. (B) Quantitation of cf-mtDNA/cf-nDNA ratio using the following mitochondrial and nuclear targets: MT-ND1/GAPDH, MTND1/TERT, MT-ND6/GAPDH, and MT-ND6/TERT. Error bars represent the sample mean ± standard deviation. *P < .05, ***P < .0005, ****P < .0001, nonparametric Kruskal-Wallis test with Dunn’s multiple-comparison test. cf-nDNA, cell-free nuclear DNA. See the complete Figure 1 in the article by Tumburu et al that begins on page 3116.

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