The ADC VLS-101 binds ROR1 on the surface of Richter syndrome (RS) cells. Upon rapid internalization of the ADC, the cytotoxin monomethyl auristatin E (MMAE) is released into the cytosol and kills the RS cell.

The ADC VLS-101 binds ROR1 on the surface of Richter syndrome (RS) cells. Upon rapid internalization of the ADC, the cytotoxin monomethyl auristatin E (MMAE) is released into the cytosol and kills the RS cell.

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