Mechanisms underpinning the generation of TEPs. Tumor-derived factors can educate mature platelets within blood circulation through several modalities. Direct mechanisms include the transfer of RNA or protein cargo via exosomes, or receptor-mediated endocytosis of soluble factors within circulation. Indirect education largely encompasses signal-dependent changes in RNA processing, most notably though alternative RNA splicing, but potentially through additional regulation of mature RNA transcripts. Tumor-derived factors may also alter the development and function of MKs within the bone marrow, resulting in a distinct platelet population that enters circulation.