Mutational status of patients with CLPD-NK. (A) A heat map of the FCM profile and mutations detected by targeted HTS for the 41 patients with CLPD-NK and 45 with reactive NK cells. The percentage of mutations for each gene was compared by using Fisher’s exact test. *P < .05. (B) Lolliplots showing the distribution of STAT3 and TET2 mutations detected in this study, with their functional interpretation.