Effectiveness of the different therapeutic strategies in patients with VEXAS syndrome. Kaplan-Meier curves of time to next treatment are presented for immunosuppressive drugs (corticosteroids, n = 10; methotrexate, n = 3) (A), cytokine inhibitors (anti-IL-6 receptor [Anti-IL6R], n = 4; anti-TNF-α [Anti-TNFa], n = 3) (B), intracellular signaling inhibitors (cyclosporine, n = 3; anti-JAK, n = 3) (C), and the hypomethylating agent azacytidine (n = 4) (D). Data were censored at time of last visit or death. The response to corticosteroids is reported as a dotted line in all the panels to allow easier comparison.