American Society of Hematology

YBX1 interacts with the m6A reader IGF2BP proteins to stabilize m6A-modified transcripts, including MYC and BCL2. Upon YBX1 inactivation, MYC and BCL2 undergo accelerated decay, thus compromising AML cells. However, the loss of YBX1 has no major impact on normal multilineage hematopoiesis.

YBX1 interacts with the m⁶A reader IGF2BP proteins to stabilize m⁶A-modified transcripts, including MYC and BCL2. Upon YBX1 inactivation, MYC and BCL2 undergo accelerated decay, thus compromising AML cells. However, the loss of YBX1 has no major impact on normal multilineage hematopoiesis.

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