Significantly affected granule and bleeding disorder proteins. (A) Raw label free quantitation (LFQ) intensities were plotted for Reactome defined granule proteins for controls and each TF mutant. See supplemental Table 5 for complete list of granule associated proteins that were identified in platelet granule proteomic studies.^9,10  Asterisks above or below the plotted LFQ values represent significantly differential expressed proteins to be up- and downregulated, respectively. The asterisks on the x-axis indicates complete absence of SERPINE1 in GFI1B mutant cases and TIMP3 in GATA1 mutant cases. (B) Raw LFQ intensities were plotted for inherited bleeding disorder associated proteins for controls and each TF mutant. Asterisks represent significantly downregulated proteins. The asterisk on the x-axis indicates complete absence of SERPINE1 in GFI1B mutant cases.