PFS by independent review of the ITT population. (A) Kaplan-Meier analysis of PFS by independent review of the ITT population. (B) Forest plots of PFS in prespecified subgroups based on patient and disease characteristics of the ITT population. *Expanded high-risk category includes del(17p), t(4;14), t(14;16), and amp(1q21) abnormalities; standard (std) risk category includes normal results as well as all types of abnormalities other than t(4;14), t(14;16), del(17), or amp(1q21); unclassifiable for expanded high risk is defined as patients who do not have cytogenetic data that can be categorized to expanded high risk or std risk corresponding to expanded high-risk group, because of either missing, unknown or indeterminate results. †High-risk category includes del(17p), t(4;14), or t(14;16) abnormalities; std risk category includes normal results as well as all types of abnormalities other than t(4;14), t(14;16), or del(17); unclassifiable for high risk is defined as patients who do not have cytogenetic data that can be categorized to high risk or std risk corresponding to high risk group, either because of missing, unknown, or indeterminate results. BPI-SF W P, Brief Pain Inventory-Short Form worst pain; CI, confidence interval; Exp., expanded; NE, not evaluable; R-ISS, revised ISS.