Transcriptional profiling of HUVEC responses to poly(I:C) and thrombin. (A) The Venn diagram shows the number of treatment-regulated genes in HUVECs in response to a 3-hour exposure to thrombin (5 nM), poly(I:C) (12.5 μg/mL), or both. Venn sections are labeled (A) to (G), with the number of upregulated (red font) and downregulated (black font) differentially expressed genes (>1.5-fold change, P_adj. ≤ .05, measured with DESeq2 v1.22.1) indicated in each section. (B) Heat maps show the log₂-fold differences in the abundance of all transcripts in sections E and F, and the most highly regulated transcripts in Venn sections G and C.