Effects of 5C12 anti-FXII antibody treatment on renal, hepatic, and pancreatic damage and function parameters in baboons infused with a lethal dose of HI-SA (LDSA). Time course changes of plasma levels of kidney function biomarkers: blood urea nitrogen (BUN) (A), and creatinine (B), liver injury biomarker alanine aminotransferase (ALT) (C), pancreas injury biomarker amylase (D), and glucose regulation (E). Same time points are compared between the control baboons (LDSA) and the 5C12-treated animals (LDSA + 5C12) using the generalized least squares (gls) function. *P < .05; **P < .01; ***P < .001. The overall P value (pvl) describing the difference between the 2 curves is shown on each graph. P < .05 is considered significant.