Figure 4.
CD8+ T cells restrain CLL progression. (A) Schematic representation of the experiment. (B) Mean ± standard deviation of the relative contribution of CD19+CD5+ cells to the entire B-cell pool in peripheral blood. Statistical significance was analyzed by Student t test: *P < .05, ***P < .001. Each point represents a single mouse. (C) Survival (Kaplan-Meier plot) of mice. Statistical analyses were performed using the log-rank test: C57 vs TCL1+/+, P < .0001; C57 vs TCL1+/+TAP−/−, P < .0001; TCL1+/+ vs TCL1+/+TAP−/−, P = .0002. Mice were included in the analysis after disease-mediated death or when they became moribund.

CD8+ T cells restrain CLL progression. (A) Schematic representation of the experiment. (B) Mean ± standard deviation of the relative contribution of CD19+CD5+ cells to the entire B-cell pool in peripheral blood. Statistical significance was analyzed by Student t test: *P < .05, ***P < .001. Each point represents a single mouse. (C) Survival (Kaplan-Meier plot) of mice. Statistical analyses were performed using the log-rank test: C57 vs TCL1+/+, P < .0001; C57 vs TCL1+/+TAP−/−, P < .0001; TCL1+/+ vs TCL1+/+TAP−/−, P = .0002. Mice were included in the analysis after disease-mediated death or when they became moribund.

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