Number of selected AESIs by period. Bars show the number of patients with each AESI occurring in the first 6 cycles and newly occurring in the second 6 cycles, in years 2 and 3, and so on. Numbers in brackets show the number of patients with a first event. Denominators are the number of patients on treatment during the indicated time window. (The incidence of certain AESIs appear higher in later time windows than in previous time windows, owing to a lower number of patients receiving treatment).