MCL cells modulate cytokine expression in the macrophages. The mRNA expression of IL-10 in CD14-Mφ (A) or THP-1-Mφ (B) was measured by qRT-PCR after direct coculturing with Mino, Granta, or Jeko or treatment with MCL CM or cytokine stimulation. IL-12 (C-D) and TNF-α (E-F) expression was measured in CD14⁺-Mφ or THP-1-Mφ after direct coculturing with Mino, Granta, or Jeko cells or treatment with MCL CM or cytokine stimulation. IL-10 secretion was measured by enzyme-linked immunosorbent assay in the supernatant of cocultured media from CD14-Mφ (G) or THP-1-Mφ (H) with Mino and Granta cells. Data are presented as mean ± standard deviation from 3 separate experiments. **P < .01, ***P < .001.