Identification of a body mass–associated plasma protein signature at 2 measurement time points. (A) Proteins selected in LASSO-regularized regression models with BMI as the continuous dependent variable: (i) all BMI-related proteins selected at the baseline measurement and (ii) those proteins selected at the follow-up measurement (12 months postindex event). The full model specifications and results, including adjustment covariates, are shown in supplemental Tables 4 and 5. (B) Selection of overlapping proteins between the baseline and follow-up measurement time points. The intersection of the proteins from both models (these are highlighted in red in panel A) was selected as robustly associated with BMI.