Figure 3.
Relationship of body mass–associated protein signature with recurrent VTE or death. Shown in this figure are the age- and sex-adjusted HRs with 95% CIs from a Cox regression model incorporating the 11 BMI-related proteins as identified in the proteomic analysis, predicting the combined recurrent VTE or death end point. In this model, proteins were transformed in accordance with the previously LASSO-selected transformation associated with the highest λ ratio. HRs reflect the increase or reduction in hazard per standard deviation increase in concentration of a given protein. CLEC4C, C-type lectin domain family 4 member C; FABP4, fatty acid–binding protein; Flt3L, Fms-related tyrosine kinase 3 ligand; IL-17C, interleukin-17C; LEP, leptin; LYVE1, lymphatic vessel endothelial hyaluronic acid receptor 1; MASP1, Mannan-binding lectin serine protease 1; ST2, ST2 protein; THBS2, thrombospondin-2; THBS4, thrombospondin-4; TSLP, thymic stromal lymphopoietin.

Relationship of body mass–associated protein signature with recurrent VTE or death. Shown in this figure are the age- and sex-adjusted HRs with 95% CIs from a Cox regression model incorporating the 11 BMI-related proteins as identified in the proteomic analysis, predicting the combined recurrent VTE or death end point. In this model, proteins were transformed in accordance with the previously LASSO-selected transformation associated with the highest λ ratio. HRs reflect the increase or reduction in hazard per standard deviation increase in concentration of a given protein. CLEC4C, C-type lectin domain family 4 member C; FABP4, fatty acid–binding protein; Flt3L, Fms-related tyrosine kinase 3 ligand; IL-17C, interleukin-17C; LEP, leptin; LYVE1, lymphatic vessel endothelial hyaluronic acid receptor 1; MASP1, Mannan-binding lectin serine protease 1; ST2, ST2 protein; THBS2, thrombospondin-2; THBS4, thrombospondin-4; TSLP, thymic stromal lymphopoietin.

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