Protective effect of leptin on recurrent VTE and death depends on leptin sensitivity. (A) Total sample. Low and high BMI (B-C) and MMP-2 (D-E) were defined as below or equal to median BMI/MMP-2 or above median BMI/MMP-2, respectively. P values were calculated with log-rank tests. Interactions between high leptin levels and BMI and MMP-2 were significant and are reported in detail in supplemental Tables 8 and 9.