The HSC AS is highly enriched for membrane-associated genes. (A) Classification of the proteins-coding AS genes by cellular compartment. The localization of each protein was determined using UniProt classification. Colors of the bars represent upregulation (red) or repression (blue) upon aging of AS genes. Numbers next to the bars indicate the number of genes found in each category. (B) Network representation of the aging genes based on the cellular compartment where the encoded proteins are predicted to be localized. The size of each circle represents the number of genes found in each category. Connections between each cellular compartment reflect the number of genes which are shared per cellular compartment. (C-D) GO analysis of biological process for AS genes. Horizontal bar represent individual GO terms (y-axis) and their log-transformed false discovery rate (FDR) values (x-axis). Numbers in each bar demonstrate the number of genes found per GO term. Red (C) and blue (D) bars represent GO terms found to be significantly enriched in upregulated and downregulated AS genes, respectively. GO terms are selected based on an FDR <0.05 cutoff.