Myeloid norbin deficiency increases immunity during pneumococcal infection and septic peritonitis. Pneumococcal infection. Mice of the indicated genotypes were infected intranasally with 2 × 10⁶S pneumoniae (filled symbols), or were mock-infected (open symbols), and culled after 6 hours (A) or after 18 hours (B). BALs were assessed for bacterial burden by quantification of CFU and for numbers of neutrophils (CD11b^hi, Ly6G^hi), alveolar macrophages (CD11c⁺, SiglecF⁺), and monocytes/macrophages (CD11c⁺, SiglecF⁺; CD11b⁺, Ly6G^lo; and CD11b⁺, Ly6C⁺) by flow cytometry. Data are mean ± standard error of the mean, pooled from 4 independent experiments for panel A or 5 for panel B; dots represent individual mice, typically 1 mock-infected and 2 to 3 infected mice per genotype per experiment. Statistics comprised Kruskal-Wallis analysis with Dunn’s multiple comparisons test. (C) Septic peritonitis. Mice were infected intraperitoneally with 1 × 10⁵E coli (filled symbols), or were mock-infected (open symbols), and culled after 3 hours. Peritoneal lavages were assessed for bacterial burden by quantification of CFU and for numbers of neutrophils and total peritoneal leukocytes by using microscopy. Data are mean ± standard error of the mean, pooled from 3 independent experiments, with 1 mock-infected and 1 to 3 infected mice/genotype/experiment; dots represent individual mice. Statistics comprised two-way analysis of variance with Šidák’s multiple comparisons test.