Univariate analyses of risk factors associated with failure of TRAs. Risk factors for TRA failure were identified using the model of Fine and Gray, considering deaths and AEs unrelated to TRA treatment or ITP as competing risks. Single comorbidities and CVRFs were tested and were not associated with TRA failure: hypertension (P = .43), overweight (P = .50), dyslipidemia (P = .24), smoking (P = .60), diabetes (P = .63), solid neoplasia (P = .14), acute myocardial infarction (P = .23), peripheral vascular disease (P = .25), chronic kidney disease (P = .32), chronic obstructive pulmonary disease (P = .84), liver disease (P = .85), peptic ulcer (P = .42), congestive heart failure (P = .62), and transient ischemic attack/stroke (P = .68) (data not shown). Multivariable analysis was not carried out because only 1 covariate had a P value < .10 in univariate analyses.