MARCKS in CLL and normal B cells. (A) MARCKS transcript expression signal intensity of normal naive, IgG memory, and IgM memory B cells isolated from peripheral blood (PB) and M-CLL and UM-CLL tumor cells from 5 donors each. (B-C) Immunoblot for MARCKS expression in M-CLL and UM-CLL (B) and corresponding densitometric analysis (C) of n = 36 patients. (D) Relative messenger RNA (mRNA) expression of MARCKS in M-CLL and UM-CLL in 337 patients. (E) Correlation of MARCKS expression with PFS of 337 patients with CLL treated with FC or FCR. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.