Heatmap of the most frequently mutated genes in each disease entity. Disease entities with ≥6 samples in the validation cohort (n = 270) are included in the study. Each row represents a gene, ordered by the frequency of mutations across all disease entities, with the most frequently mutated gene at the top. Each column represents a disease entity, with the number of samples assessed in parentheses. The color represents the percentage of samples in a particular disease entity, identified with a mutation in each specific gene. AITL, angioimmunoblastic T-cell lymphoma; MZL, marginal zone lymphoma.