Patients’ BM contains a reduced number of HSCs and progenitors. (A-E) The absolute number of various cell lineages and progenitors was estimated in the BM of 3 patients with DADA2 by multidimensional flow cytometry and compared with a cohort of 12 adult HDs. Data are presented as violin plots. CMP, common myeloid progenitors; DC, dendritic cells; EP, erythroid progenitors. ETP, early T-cell progenitors; GMP, granulocyte-monocyte progenitors; iPMN, immature polymorphonuclear cells; MEP, megakaryocyte-erythroid progenitors; MKp, megakaryocyte progenitors; MLP, multilymphoid progenitors; MPP, multipotent progenitors; PMN, mature polymorphonuclear cells; Pre-BNK, pre-B and NK progenitors; Pro-lympho, pro-lymphocytes. *P < .05, **P < .01.