TERT variants in MDS and NHL. (A) Classification approach of nonsynonymous TERT coding variants identified in the MDS and NHL cohorts. (B) Frequency of TERT common and TERT rare variants within the MDS and NHL cohorts. (C) Domain distribution of TERT variants within the MDS cohort. TERT common variants (n = 180) and rare variants (n = 41, R1086H in 2 patients) are located above and below the coding region, respectively. The size of each ball is proportional to the number of patients with that variant. TERT rare variants are colored in red and TERT common variants in blue.