Plasma analytes with significant differences between HLH and sepsis/SIRS. (A) Heatmap demonstrates relative concentration of analytes with significant differential expression (FDR < 0.1) revealed by supervised comparison of HLH and SIRS/sepsis datasets. All subjects in this study are shown with heatmap reflecting relative concentrations of analytes with significant differential expression between HLH and sepsis or SIRS in both training and validation cohorts. (B) Subjects were split into training and validation cohorts, without reference to cytokine values, and analyzed separately. Values of analytes with differential expression between HLH and SIRS/sepsis datasets are displayed for training and validation cohorts.