Recombinant human ADAMTS13 and plasma transfusion reduce the deranged ADAMTS13-VWF axis, associated with decreased VWF-platelet thrombi in the lung. Data are shown as boxplots with range. (A-E) Before trauma (T = 0) and 6 hours post-trauma, samples were analyzed for different measures, including VWF antigen (A), rat ADAMTS13 antigen (B), human ADAMTS13 antigen (C), HMW VWF multimers (D), and platelet counts (E). (F) At termination, the lung was assessed for VWF-platelet microthrombi. (G-I) Images (original magnification ×400) of the lung for the assessment of VWF (blue), CD41 + platelets (red), and microthrombi (purple). The arrow in (G) points towards a microthrombus. *P < .05, **P < .01, and ***P < .001 between groups; #P < .05 within groups.