Blood investigation trends. (A) Changes in levels of key blood factors after massive FFP transfusion and hemostatic surgery on day 1 (D1). The patient had a second intra-abdominal hemorrhage on day 6 (D6), requiring another emergency hemostatic surgery. Eighteen units of FFP were also administered after the hemorrhage. (B) Changes in fibrinogen, FDP, and D-dimer levels after rhTM infusions (380 U/kg) administered IV once daily from days 7 through 9 and days 11 through 14. After rhTM infusions were stopped, nafamostat mesylate and tranexamic acid (TA) were administered beginning on day 16. Large FFP transfusions occurred daily from days 17 through 20. (C) The effect of continued nafamostat mesylate and TA treatment followed by reinfusion with rhTM on the levels of coagulation factors over time. On day 36, the daily dosing interval of rhTM was extended to every 2 to 3 days. (D) Changes in levels of key blood coagulation factors followed by infusion with rhTM from days 29 through 34. UFH, unfractionated heparin.