Genomic analysis identifies novel putative tumor suppressors and oncogenes in CTCL. (A) Histogram of SCNVs in CTCL. G-scores calculated by GISTIC2.0 reflect frequency and amplitude of the SCNVs identified. Red represents statistically significant amplifications and blue indicates statistically significant deletions. Residual q < 0.25, by GISTIC2.0. (B) Histogram of percentage of CTCL samples harboring novel putative CTCL tumor suppressors. These tumor suppressors were newly identified by the current SCNV analysis. (C) Diagram of BACH2 structural variants. P-value indicates Bonferroni correction of the binomial distribution probability of the observed number of translocations occurring by chance (see “Methods”). (D) Novel hotspot point mutations in CTCL. Lollipop plots depict observed SSNVs in T-cell lymphoma samples and structural models of NFKB1 (in complex with DNA PDB [protein database]: 1VKX), JUNB (mapped onto the cocrystal structure of c-Jun homodimer complexed with DNA, PDB: 5T01) and TBL1XR1 (complexed with MeCP2, PDB: 5NAF). (E) Lollipop plots depicting novel tumor suppressors with a significant burden of damaging mutations identified in CTCL. CTX, chromosomal translocation. GISTIC, Genomic Identification of Significant Targets in Cancer.