Transcriptional heterogeneity of mouse and human BM MKs. (A) UMAP plot of all MKs that passed quality control tests (795 cells). (B) Bar graph showing the number of cells at each ploidy stage in 4 clusters. (C) Heatmap displaying the cluster-specific DEGs in mouse MKs. The enriched biological processes for each gene group are shown on the right. (D) Dot plot representing relative expression for selected genes involved in indicated biological processes in mouse MKs. Dot size indicates the proportion of cells in a cluster that express a gene; shading (low, light; high, dark) indicates the relative level of expression. (E) Heatmap showing cluster-specific DEGs that are similar between human and mouse MKs. The enriched biological processes for each gene group are shown on the right. (F) Bar plot showing the distribution of ploidy degree of each cluster in mouse and human MKs. H, human; M, mouse.