Figure 1.
Schematic illustration of the sequences/structures of IREs. (A) Schematic illustration of the structures of typical (type I) IRE stem loops in the 5′ UTRs of the mRNAs of erythroid delta aminolevulinic acid synthase (eALAS), hypoxia inducible factor-2α (HIF-2α), mitochondrial aconitase 2 (mACO2), ferroportin, FTH, FTL, and CD63 relative to the atypical (type II) IREs in the 5′ UTR of α-synuclein and amyloid precursor protein (APP). (B) Schematic illustration of the structures of typical (type I) IRE stem loops in the 3′ UTR regions of the mRNAs of divalent metal ion transporter 1 (DMT1), transferrin receptor 1 (TfR1; 5 TfR1 IREs are denoted: A-E), cell division cycle 14A (CDC14A) and myotonic dystrophy kinase–related CDC42-binding kinase-α (MRCKα). n.d., not determined.

Schematic illustration of the sequences/structures of IREs. (A) Schematic illustration of the structures of typical (type I) IRE stem loops in the 5′ UTRs of the mRNAs of erythroid delta aminolevulinic acid synthase (eALAS), hypoxia inducible factor-2α (HIF-2α), mitochondrial aconitase 2 (mACO2), ferroportin, FTH, FTL, and CD63 relative to the atypical (type II) IREs in the 5′ UTR of α-synuclein and amyloid precursor protein (APP). (B) Schematic illustration of the structures of typical (type I) IRE stem loops in the 3′ UTR regions of the mRNAs of divalent metal ion transporter 1 (DMT1), transferrin receptor 1 (TfR1; 5 TfR1 IREs are denoted: A-E), cell division cycle 14A (CDC14A) and myotonic dystrophy kinase–related CDC42-binding kinase-α (MRCKα). n.d., not determined.

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