MB1-47 shows antileukemic effects in human T-ALL PDXs in vivo. (A) Kaplan-Meier survival curve of mice harboring PDTALL19, a NOTCH1-mutated PTEN⁺ human T- ALL PDX, treated with a control diet or an MB1-47–containing diet (n = 10 mice per group). (B) Kaplan-Meier survival curve of mice harboring CU-L-157, a NOTCH1–wild-type PTEN⁻ human T- ALL PDX, treated with a control diet or an MB1-47–containing diet (n = 6 mice per group). P values were calculated with the log-rank test. **P < .01; ***P < .005.