Cohesin complex mutations in myeloid malignancies. The core members of the cohesin complex ring and its loader complex (A) and the frequency of mutations (B) according to diagnostic subgroup: de novo AML (n = 2170)8,15,128 ; NPM1-mutant AML (n = 418)15 ; FLT3-ITD-mutant AML (n = 341)15 ; t(8;21) AML (n = 254)15,32,49 ; inv(16) AML (n = 189)32,49,129 ; MDS (n = 1596)35,38 ; sAML (n = 93)130 ; AML-MRC (n = 106)8,18 ; CMML (n = 224)8,131 ; pediatric MDS (n = 38)39 ; pediatric AML (n = 993)129 ; and DS-AMKL (n = 190).41,42 Mutation frequency was calculated as frequency of positive reported cases within the total tested cohort in a single study or averaged across multiple available cohorts. AML-MRC, AML with myelodysplasia-related changes; CMML, chronic myelomonocytic leukemia; DS-AMKL, Down syndrome–associated acute megakaryoblastic leukemia.