Sister chromatid cohesion–dependent functions of the cohesin complex. (A) Cohesin stabilizes replication forks during DNA replication and restarts stalled replication forks. (B) Cohesin is actively recruited to sites of DNA double-strand breaks to bring the damaged sister chromatid in close proximity of its nondamaged sister chromatid to be used as a donor template during the process of homologous recombination-mediated repair.